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- W2368669985 abstract "OBJECTIVE:To establish a method for the determination of the related substances of Azithromycin suspension.METHODS:HPLC was adopted using Venusil XBP-C18 as column.The mobile phase consisted of 0.05 mol·L-1 dibasicsodium phosphate buffer solution(pH value adjusted to 8.2 by 20% phosphoric acid)-acetonitrile(47:53).The injection volume was 20 μL and the flow rate was 1.2 mL·min-1.UV detection wavelength was set at 210 nm.RESULTS:The resolution was 1.92 after experimental light damage,and it was 2.16 after heat damage test.After treated with acid,resolution of sample was 1.76,and it was 7.88 and 2.11 in alkali destruction test and oxidative damage test.The related substances were 2.41%,2.45% and 2.43%.CONCLUSION:The method is simple,sensitive and accurate for the determination of the related substances of Azithromycin suspension." @default.
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- W2368669985 date "2011-01-01" @default.
- W2368669985 modified "2023-09-25" @default.
- W2368669985 title "Determination of Related Substances of Azithromycin Suspension by HPLC" @default.
- W2368669985 hasPublicationYear "2011" @default.
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