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- W2368670232 abstract "Objective:To determine the contents of main drugs in compound ketotifen fumarate nasal drops.Methods:An HPLC method was employed with the chromatographic column as Diamonsil C18(4.6mm×150mm,5μm,room temperature).The mobile phase was acetonitrile:ammonium acetate(pH 5.5)=10:90.The flow rate was 1.0 mL·min-1.The detection wavelength was 240 nm.Results:Ketotifen fumarate has a good linearity over the range of 40.0～160.0 μg·mL-1,with the regression equation of A=1.178C-5.193,r=0.9995(n=7).The average recovery rate was 100.61%,RSD was 0.49%(n=5).Ephedrine hydrochloride has a good linearity at the range of 200.0～800.0 μg·mL-1,with the regression equation of A=0.3680C-6.455,r= 0.9993(n=7).The average recovery rate was 99.99%,RSD was 0.38%(n=5).Nitrofurazone has a good linearity over the range of 8.0～30.0 μg·mL-1,with the regression equation of A=66.58C-4.103,r=0.99987(n=7).The average recovery rate was 98.69%,RSD was 0.92%(n=5).Conclusion:The proposed method is simple,specific,and can be used in the content determination of ketotifen fumarate,ephedrine hydrochloride and nitrofurazone in compound Ketotifen fumarate nasal drops." @default.
- W2368670232 created "2016-06-24" @default.
- W2368670232 creator A5063496433 @default.
- W2368670232 date "2010-01-01" @default.
- W2368670232 modified "2023-09-23" @default.
- W2368670232 title "Content Determination of Three Main Drugs in Compound Ketotifen Fumarate Nasal Drops by HPLC" @default.
- W2368670232 hasPublicationYear "2010" @default.
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