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- W2368685999 abstract "[Objective]To investigate the expression of the CXC chemokine cytokine-induced neutrophil chemoattractant (CINC)in severe acute pancreatitis (SAP)and to examine the effects of QingYiTang(QYT)on the course of pancreatitis-associated acute lung injury (ALI).[Methods]SD rats induced by homogeneous injection of 0.4ml/㎏ of 5 percent sodium taurocholate beneath the pancreatic capsule were treated with QYT.After 6,12 and 24 hours,tissue edema was deter-mined by wet/dry weight ratios and myeloperoxidase(MPO)activity of lungs were measured;pathological changes in the pancreas and lungs were observed;expression of CINCmRNA and TNF-αconstration in lungs were determined by reverse transcriptase polymerase chain reaction (RT-PCR)or enzyme-linked immunosorbent assay (ELISA).[Results]Compared with that in shams,wet/dry weight ratios,pulmonary expression of CINC gene,MPO activity,TNF-αconcentrations in the lungs and the serum amylase were increased greatly in 24 hours(P0.05).The CINCmRNA expression in lungs was significantly correlated with the severity of lung injury,MPO activity and TNF-αconcentrations in the lungs(P0.05).administration of QYT significantly decreased the elevation of MPO activity,wet/dry weight ratios ,TNF-αconcentrations and CINCmRNA expression in the lung(P0.05),and improved the histological findings(P0.05).[Conclusion]Overexpression of CINC mRNA in the lungs might play an important role in the pathogenesis of ALI in SAP.QYT reduced the severity of ALI,suggesting a possible application of this compound in the treatment of acute pancreatitis." @default.
- W2368685999 created "2016-06-24" @default.
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- W2368685999 date "2009-01-01" @default.
- W2368685999 modified "2023-09-23" @default.
- W2368685999 title "Expression of cytokine-induced neutrophil chemoattractant in pancreatitis-associated lung injury and the therapeutic effects of Qingyitang" @default.
- W2368685999 hasPublicationYear "2009" @default.
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