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- W2368693067 abstract "To study action of IL-1 involved in neurotoxicity. Methods: The effects of IL-1ra(IL-1 receptor antagonist, IL-1ra) on glutamate-induced neurotoxicity were examined using cultured ratcortical neurons with Trypan blue exclusion and scan electromicroscope. Meanwhile, effects of IL-1β onexpression of NMDAR1 mRNA were observed in cultures. Results: IL-1ra (1mg/L) may significantlyinhibit neuronal damage induced by glutamate at concentration of 0. 5 mmol/L F IL-1β dose-deppndentlypromoted expression of NMDAR1 mRNA in cultures at dose of 1～50 u/ml IL-1ra may reverse the action of IL-1β. Conclusion: Endogenous IL-1 mediates pathological procession of llPuronal damage induced by glutamate, and one possibility of IL-1 involved in neurotoxicity is to stimulate expression ofNMDAR1 mRNA" @default.
- W2368693067 created "2016-06-24" @default.
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- W2368693067 date "1997-01-01" @default.
- W2368693067 modified "2023-09-25" @default.
- W2368693067 title "IL-1ra-INDUCED PROTECTION OF CULTURED RAT CORTICAL NEURONS AGAINST GLUTAMATE NEUROTOXICITY" @default.
- W2368693067 hasPublicationYear "1997" @default.
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