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- W2368694943 abstract "Objective To investigate the preparation and to determine the dissolution behavior of the paracetamol,loratadine and pseudoephedrine sulfate sustained release tablets.Methods By using HPMC as sustained-release matrix material,paracetamol,loratadine and pseudoephedrine sulfate sustained release tablets were prepared by wet granulation.The optimum formulation was selected by studying on the release degree of paracetamol in vitro via orthogonal test.The factors affecting the release rate of paracetamol in vitro from matrix,including particle size of paracetamol,quantity of HPMC and Ca(HCO3)2,moisture in granules and tablets pressure were evaluated.Results The particle size of paracetamol,the quantity of HPMC,the moisture in granules and the tablets pressure were found to be the sole factors that affected the release rate of paracetamol.The quantity of Ca(HCO3)2 showed no significant effects on the release rate.Conclusion The paracetamol,loratadine and pseudoephedrine sulfate sustained release tablets prepared according to the optimized formulation show significant sustained release behavior,and comply with relevant requirement,can be applied to industrial production." @default.
- W2368694943 created "2016-06-24" @default.
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- W2368694943 date "2012-01-01" @default.
- W2368694943 modified "2023-09-25" @default.
- W2368694943 title "Study on Preparation and in Vitro Release Behavior of Paracetamol, Loratadine and Pseudoephedrine Sulfate Sustained Release Tablets" @default.
- W2368694943 hasPublicationYear "2012" @default.
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