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- W2368695975 abstract "Objective This study was to investigate the antitumor effects of canstatin gene on human esophageal carcinoma xenografts in nude mice.Methods Esophageal cancer celles were implanted into BALB/c nude mice to induce tumor xenografts,tumor xenografts were randomized into three groups: PBS,adenovirus green fluorescent protein(Ad-GFP),and Ad-GFP-canstatin groups.After treatment,tumor size was measured.The expression of cyclin D1、bcl-xl mRNA Ievels were detected by RT-PCR and microvessel density(MVD) in tissue of each group were detected by immunohistochemistry.Results Compared with that in Ad-GFP and PBS groups,tumor size in Ad-GFP-canstatin group was significantly suppressed after gene transfection.Compared with Ad-GFP and PBS groups,expressions of cyclinD1 and bcl-xl in Ad-GFP-canstatin group was lower(P0.05),and microvessel density(MVD) were lower too(P0.05).Conclusion Canstatin can inhibit the growth of human esophageal carcinoma by suppressing angiogenesis via down-regulating cyclin D1 and bcl-xl expression." @default.
- W2368695975 created "2016-06-24" @default.
- W2368695975 creator A5069046238 @default.
- W2368695975 date "2010-01-01" @default.
- W2368695975 modified "2023-09-23" @default.
- W2368695975 title "Study on Effect and Significance of Canstatin Gene on Expressions of bcl-xl and Cyclin D1 on Human Esophageal Carcinoma Xenografts in Nude Mice" @default.
- W2368695975 hasPublicationYear "2010" @default.
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