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- W2368698381 abstract "The pyrethroid Permethrin is one of the most excellent insecticides. Toxicokine-tics of 14C-Permethrin was studied in rats after intratracheal injection, in comparison with intragastrio administration as control.The results showed that the curve of the logarithm of blood Permethrin concentra- tion versus time was fitted to a two-compartment open model with first order rate. The toxicokinetic parameters of the Permethrin intake through the lung were as follows: Ka0.89hr-1, T1/2a1.35hr. T1/2β4.31hr, K122/K211(0.37), Vo 146.61/kg, Cl 33.16/hr, Tmax1.56hr and Cmax 2473.28ng/ml.The level of radioactivity was highest in the abdominal fat, then, in decreasing gradient, the liver and kidney. 14C-Permethrin was eliminated in urine and faeces, especially-in the former. Kel of urine and faeces were 1.38 day-1, 0.90 day-1 respectively. Half-time of urinary elimination was 0.5 day, and faecal, 0. 77 day.The absorption was faster and elimination was slower in the administration through intratrachial than intragastric route." @default.
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- W2368698381 date "1983-01-01" @default.
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- W2368698381 title "INVESTIGATION ON TOXICOKINETICS OF PERMETHRIN IN RATS AFTER INTRATRACHEAL ADMINISTRATION" @default.
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