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- W2368705188 abstract "DNA methylation is an important cause of altered gene expression and found in many human cancers.Although the DNA methylation microarrays were widely used in cancer research,the consistency of signatures from different studies was not assessed.Also the inverse correlation between methylation and expression change was arguable.Here,using two methylation datasets of kidney renal cell carcinoma,we found the methylation changes were highly consistent across different datasets,suggesting methylation change detected from methylation microarrays were reproducible.Then by gene expression data of kidney renal cell carcinoma,we found hypermethylated genes were significantly down-regulated while hypomethylated genes were not related to expression change.Finally,we found three pathways which simultaneously showed methylation and expression change.These pathways may be helpful for mechanism research and target therapy of kidney renal cell carcinoma." @default.
- W2368705188 created "2016-06-24" @default.
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- W2368705188 date "2011-01-01" @default.
- W2368705188 modified "2023-09-25" @default.
- W2368705188 title "Reproducibility of DNA methylation signatures in kidney renal cell carcinoma and their relationship with expression change" @default.
- W2368705188 hasPublicationYear "2011" @default.
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