FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368711922> ?p ?o ?g. }

• W2368711922 endingPage "367" @default.
• W2368711922 startingPage "359" @default.
• W2368711922 abstract "Tears are a complex biological mixture containing electrolytes, metabolites, lipids, mucins, some small organic molecules, and proteins. The tear film has various roles in the lubrication, protection from the external environment, and nutrition of the cornea; it is also involved in the modulation of the optical properties of the eye. Tear composition reflects the physiological condition of the underlying tissues. Therefore, the tear fluid is useful in the evaluation of health and disease states and it is a valuable source of biomarkers for objective analysis of ocular and systemic diseases. The relatively high protein concentration of this fluid and the ease of noninvasive sample collection make it suitable for diagnostic and prognostic purposes. Efforts in proteomics research have positively affected to the field of ophthalmology, and the knowledge on the tear proteome has expanded considerably in the last few years. Nevertheless, despite a large amount of available data and the many biomarkers proposed for several eye and systemic diseases, the extent of translation to well-characterized and clinically useful tools has been largely insufficient. As for most of other biofluids, the road from discovery to clinical application is still long and full of pitfalls. In this review, we discuss the proteomic approaches used in the characterization of tear protein and peptide content, recapitulating the main studies and the progress done. We also present a brief summary of the path from discovery to clinical application of tear protein markers, with some representative examples of translation from the bench to the bedside. In this review we cover the most relevant proteomic approaches used in the characterization of the tear proteome, and for the first time we also focus in advances performed in the nowadays emerging peptide content characterization. In this context, we recapitulate on the main studies and the progresses done in this field. We also present a concise overview of the course that may be happen from discovery to clinical application for tear protein markers. Finally we include some representative examples of translation from the bench to the bedside." @default.
• W2368711922 created "2016-06-24" @default.
• W2368711922 creator A5016541873 @default.
• W2368711922 creator A5017706342 @default.
• W2368711922 creator A5042331837 @default.
• W2368711922 creator A5053687498 @default.
• W2368711922 creator A5081226781 @default.
• W2368711922 date "2017-01-01" @default.
• W2368711922 modified "2023-10-16" @default.
• W2368711922 title "Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice" @default.
• W2368711922 cites W126342968 @default.
• W2368711922 cites W1529812339 @default.
• W2368711922 cites W1968494166 @default.
• W2368711922 cites W1971308852 @default.
• W2368711922 cites W1971762511 @default.
• W2368711922 cites W1973513527 @default.
• W2368711922 cites W1978458547 @default.
• W2368711922 cites W1978465780 @default.
• W2368711922 cites W1980174408 @default.
• W2368711922 cites W1980541833 @default.
• W2368711922 cites W1985676460 @default.
• W2368711922 cites W1988188685 @default.
• W2368711922 cites W1989465803 @default.
• W2368711922 cites W1992460692 @default.
• W2368711922 cites W1994521493 @default.
• W2368711922 cites W1996684568 @default.
• W2368711922 cites W1997345884 @default.
• W2368711922 cites W1999771203 @default.
• W2368711922 cites W2002697163 @default.
• W2368711922 cites W2004023585 @default.
• W2368711922 cites W2005415233 @default.
• W2368711922 cites W2005893121 @default.
• W2368711922 cites W2006165324 @default.
• W2368711922 cites W2007044329 @default.
• W2368711922 cites W2011163417 @default.
• W2368711922 cites W2013443697 @default.
• W2368711922 cites W2014238044 @default.
• W2368711922 cites W2019241754 @default.
• W2368711922 cites W2019834739 @default.
• W2368711922 cites W2020383411 @default.
• W2368711922 cites W2020487317 @default.
• W2368711922 cites W2020999562 @default.
• W2368711922 cites W2029015528 @default.
• W2368711922 cites W2031359593 @default.
• W2368711922 cites W2032501932 @default.
• W2368711922 cites W2033625993 @default.
• W2368711922 cites W2034248704 @default.
• W2368711922 cites W2042150021 @default.
• W2368711922 cites W2042385661 @default.
• W2368711922 cites W2042794878 @default.
• W2368711922 cites W2044363194 @default.
• W2368711922 cites W2045139587 @default.
• W2368711922 cites W2045557044 @default.
• W2368711922 cites W2048333869 @default.
• W2368711922 cites W2052808939 @default.
• W2368711922 cites W2057198053 @default.
• W2368711922 cites W2057645593 @default.
• W2368711922 cites W2064534678 @default.
• W2368711922 cites W2067445716 @default.
• W2368711922 cites W2068160105 @default.
• W2368711922 cites W2072099326 @default.
• W2368711922 cites W2076361835 @default.
• W2368711922 cites W2081828996 @default.
• W2368711922 cites W2082810351 @default.
• W2368711922 cites W2082815559 @default.
• W2368711922 cites W2082924908 @default.
• W2368711922 cites W2082952072 @default.
• W2368711922 cites W2087979725 @default.
• W2368711922 cites W2088594156 @default.
• W2368711922 cites W2089463818 @default.
• W2368711922 cites W2089885086 @default.
• W2368711922 cites W2089940606 @default.
• W2368711922 cites W2090364092 @default.
• W2368711922 cites W2091427621 @default.
• W2368711922 cites W2091638840 @default.
• W2368711922 cites W2095002499 @default.
• W2368711922 cites W2095558497 @default.
• W2368711922 cites W2102911025 @default.
• W2368711922 cites W2103174201 @default.
• W2368711922 cites W2106883109 @default.
• W2368711922 cites W2113453721 @default.
• W2368711922 cites W2113761013 @default.
• W2368711922 cites W2116741394 @default.
• W2368711922 cites W2122816722 @default.
• W2368711922 cites W2125738374 @default.
• W2368711922 cites W2128381498 @default.
• W2368711922 cites W2130268926 @default.
• W2368711922 cites W2131885284 @default.
• W2368711922 cites W2136007332 @default.
• W2368711922 cites W2144239996 @default.
• W2368711922 cites W2148450076 @default.
• W2368711922 cites W2151095005 @default.
• W2368711922 cites W2152278396 @default.
• W2368711922 cites W2156216776 @default.
• W2368711922 cites W2160797468 @default.
• W2368711922 cites W2161153914 @default.
• W2368711922 cites W2163071831 @default.
• W2368711922 cites W2228980293 @default.

• next