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- W2368731679 abstract "Objective To look for the optimum solution of anti-double-stranded-DNA(anti-dsDNA) antibodies detection.Methods To address the test feature of anti-dsDNA antibodies detection by different test methods,the performances of four immunoassays were compared.These included Line Immunoassay(LIA), crithidia Luciliae Immunofluorescence test(CLIFT)and two enzyme-linked immunoassays(ELISA).The sample set included 60sera from systemic lupus erythematosus(SLE);30from other diseases(ODC)and 30from the normal control group(NC).Results The sensitivity and specificity of these four assays were 58.33%and 71.67%(LIA),56.67%and 100.00%(CLIFT),51.67%and 93.33%(ELISA-Ⅰ),73.33% and 86.67%(ELISA-Ⅱ) respectively.There were no significant differences among LIA,CLIFT and ELISA-Ⅰ(P0.05),but ELISA- Ⅱ showed the highest sensitivity(P0.01).In ROC curve analysis,ELISA-Ⅰand ELISA- Ⅱshowed AUC values of 0.764and 0.882.When calculated by using the cut-off point of ROC curve,the sensitivity and specificity of ELISA-Ⅰwere 55.00% and 91.67%;ELISA-Ⅱ were 81.67% and 83.33%.When evaluated by increasing the specificity values to 95.00%,the sensitivity of ELISA-Ⅰdecreased to 48.33%,ELISA- Ⅱ to 50.00%.Conclusion Four different assays showed various test features.Both CLIFT and ELISA are suitable for the routine test of antidsDNA antibodies in clinical laboratory.Due to the fact that ELISA showed the highest sensitivity,it can be used for screening purpose,CLIFT had the highest specificity,and can be used as a confirmation test.Regardless of the testing strategy among individual laboratories,clear communication with the clinical staff regarding the significance of a positive result is imperative.The laboratory and the clinician must both be aware of the sensitivity and specificity of each testing method used in the clinical laboratory." @default.
- W2368731679 created "2016-06-24" @default.
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- W2368731679 date "2014-01-01" @default.
- W2368731679 modified "2023-09-23" @default.
- W2368731679 title "Study on Anti-dsDNA Antibody Detection Strategies" @default.
- W2368731679 hasPublicationYear "2014" @default.
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