Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368741711> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2368741711 abstract "OBJECTIVE To investigate the change of p38 MAPK after myocardial ischemia reperfusion injury in rats and the effects of naloxone.METHODS Twenty-four SD rats were randomly divided into three groups.sham-operated group,IR group,IR and treated with Naloxone group.The myocardial ischemia reperfusion injury model was established by ligating the left anterior descending coronary artery for 30 minutes followed by reperfusion for 2 h.ECG was used to detect J dot changes.Terminal deoxynucleotidy transferase mediated dUTP fluorescein nick end labeling(TUNEL) and Western bloting were used respectively to detect the cardiomyocyte apoptosis and protein expressin of p38 MAPK and p-p38 MAPK,respectively.RESULTS In IR group ECG showed that J dot was significantly higher,and Western bloting sections showed that the expression of p38 MAPK and p-p38 MAPK were significantly higher,and TUNEL sections showed that the number of apoptotic cardiomyocytes was significantly increased,as compared to sham-operated group(P0.01).In Nal group ECG showed that J dot was significantly reduced,and Western bloting sections showed that the expression of p38 MAPK and p-p38 MAPK were significantly lower,and TUNEL sections showed that the number of apoptotic cardiomyocytes was significantly decreased,as compared to IR group(P0.01).CONCLUSION Naloxone has protective effect on cardiac muscle after the myocardial ischemia reperfusion injury,and its mechanism may be related to inhibition of the expression of p38 MAPK and p-p38 MAPK and reduction of cardiomyocyte apoptosis in rat myocardial ischemia reperfusion." @default.
- W2368741711 created "2016-06-24" @default.
- W2368741711 creator A5000246497 @default.
- W2368741711 date "2011-01-01" @default.
- W2368741711 modified "2023-10-02" @default.
- W2368741711 title "Effect of p38 MAPK on naloxone alleviating myocardial ischemia reperfusion injury in rats" @default.
- W2368741711 hasPublicationYear "2011" @default.
- W2368741711 type Work @default.
- W2368741711 sameAs 2368741711 @default.
- W2368741711 citedByCount "0" @default.
- W2368741711 crossrefType "journal-article" @default.
- W2368741711 hasAuthorship W2368741711A5000246497 @default.
- W2368741711 hasConcept C126322002 @default.
- W2368741711 hasConcept C170493617 @default.
- W2368741711 hasConcept C184235292 @default.
- W2368741711 hasConcept C185592680 @default.
- W2368741711 hasConcept C190283241 @default.
- W2368741711 hasConcept C196795494 @default.
- W2368741711 hasConcept C2778750930 @default.
- W2368741711 hasConcept C2780114680 @default.
- W2368741711 hasConcept C2781063702 @default.
- W2368741711 hasConcept C51551487 @default.
- W2368741711 hasConcept C541997718 @default.
- W2368741711 hasConcept C55493867 @default.
- W2368741711 hasConcept C57074206 @default.
- W2368741711 hasConcept C71924100 @default.
- W2368741711 hasConcept C98274493 @default.
- W2368741711 hasConceptScore W2368741711C126322002 @default.
- W2368741711 hasConceptScore W2368741711C170493617 @default.
- W2368741711 hasConceptScore W2368741711C184235292 @default.
- W2368741711 hasConceptScore W2368741711C185592680 @default.
- W2368741711 hasConceptScore W2368741711C190283241 @default.
- W2368741711 hasConceptScore W2368741711C196795494 @default.
- W2368741711 hasConceptScore W2368741711C2778750930 @default.
- W2368741711 hasConceptScore W2368741711C2780114680 @default.
- W2368741711 hasConceptScore W2368741711C2781063702 @default.
- W2368741711 hasConceptScore W2368741711C51551487 @default.
- W2368741711 hasConceptScore W2368741711C541997718 @default.
- W2368741711 hasConceptScore W2368741711C55493867 @default.
- W2368741711 hasConceptScore W2368741711C57074206 @default.
- W2368741711 hasConceptScore W2368741711C71924100 @default.
- W2368741711 hasConceptScore W2368741711C98274493 @default.
- W2368741711 hasLocation W23687417111 @default.
- W2368741711 hasOpenAccess W2368741711 @default.
- W2368741711 hasPrimaryLocation W23687417111 @default.
- W2368741711 hasRelatedWork W1212653585 @default.
- W2368741711 hasRelatedWork W2347249785 @default.
- W2368741711 hasRelatedWork W2349625230 @default.
- W2368741711 hasRelatedWork W2352451463 @default.
- W2368741711 hasRelatedWork W2354698405 @default.
- W2368741711 hasRelatedWork W2357244159 @default.
- W2368741711 hasRelatedWork W2360943106 @default.
- W2368741711 hasRelatedWork W2362283491 @default.
- W2368741711 hasRelatedWork W2366063889 @default.
- W2368741711 hasRelatedWork W2367478786 @default.
- W2368741711 hasRelatedWork W2369195428 @default.
- W2368741711 hasRelatedWork W2371632200 @default.
- W2368741711 hasRelatedWork W2372082253 @default.
- W2368741711 hasRelatedWork W3024231091 @default.
- W2368741711 hasRelatedWork W3029877153 @default.
- W2368741711 hasRelatedWork W3030295486 @default.
- W2368741711 hasRelatedWork W3031521500 @default.
- W2368741711 hasRelatedWork W3032299365 @default.
- W2368741711 hasRelatedWork W3032468726 @default.
- W2368741711 hasRelatedWork W3149228912 @default.
- W2368741711 isParatext "false" @default.
- W2368741711 isRetracted "false" @default.
- W2368741711 magId "2368741711" @default.
- W2368741711 workType "article" @default.