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- W2368744530 abstract "Objective To investigate the difference of uncoupling protein 2(UCP2) expression between the hypothalamus and hippocampus in diabetic mice. Methods After the mice models of type 2 diabete mellitus were established by high fat diet with low dose STZ injection,the mice were assigned to three groups of A(model control), B(treated with UCP2 inhibitor genipin 5 mg·kg-1·d-1 for 2 weeks) and C(treated with genipin 10 mg·kg-1·d-1) with 12 rats each.The expressions of UCP2 mRNA and protein in the hypothalamus and hippocampus were detected.The results were compared to those in the healthy control mice. Results Compared to healthy mice,UCP2 expression was not significantly different in the hypothalamus,but UCP2 mRNA expression was higher in the hippocampus in group A(P0.05).Compared to group A,the UCP2 expressions in the hypothalamus and hippocampus were nonlineally decreased in groups of B and C. Conclusion The difference in UCP2 expression exists between the hypothalamus and hippocampus in diabetic mice." @default.
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- W2368744530 date "2012-01-01" @default.
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- W2368744530 title "Difference of UCP2 expression between the hypothalamus and hippocampus in diabetic mice" @default.
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