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- W2368746481 abstract "OBJECTIVE To observe the changes of peripheral blood T lymphocytes, IFN-gamma, TNF-alpha and IL.4 in rats infected by T gondii. METHODS 48 Sprague-Dawley(SD) rats were intra-abdominally injected with 2 x 10(5)/L of cellulose purified living tachyzoites in 2 ml and randomly divided into 8 groups Six rat was intra-abdominally injected 2 ml of saline as control and 4 rats were remained as normal control. Peripheral blood was collected and the level of IFN-gamma, TNF-alpha, IL-4 was analyzed by ELISA on day 1, 3, 7, 14, 28, 35, 42, 60. RESULTS Level of IFN-gamma (6.73 pg/nil) and IL-4 (6.91 pg/ml) increased in experimental rats on day 7 (P < 0.05) and maintained. Level of TNF-alpha (14.37 pg/ml) increased in experimental rats on day 28 (P < 0.05), and that of CD8+ T lymphocytes (14.22%) was signficantly lower than that in control (23.08%) (P < 0.05) and recovered on day 28. No considerable change was observed on the level of CD4 T lymphocytes. CONCLUSION The level of CD8 T lymphocytes, IFN-gamma, TNF-alpha and IL-4 in the rat can be affected by the infection of T. gondii and the level of CD4+ T lymphocytes shows no change." @default.
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- W2368746481 date "2006-04-30" @default.
- W2368746481 modified "2023-09-23" @default.
- W2368746481 title "[Changes of peripheral blood T lymphocytes, IFN-gamma, TNF-alpha and IL-4 in rats infected by Toxoplasma gondii]." @default.
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