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- W2368748922 abstract "Objective:To investigate the relationship between paraoxonase 2 (PON2) C311S gene polymorphism and patients with 2 type diabetes mellitus (type 2 DM) complicated with nephropathy in Zhengzhou—apopulation of han nationality. Methods:PON2 C311S gene polymorphism was detected by PCR-RFLP, serum cholesterol, triglyceride, high-density lipoprotein cholesterol ,low-density lipoprotein cholesterol and oxidized low density lipoprotein were determined in serum for 122 patients with 2 type diabetes mellitus (DM), 121 DM complicated with microalbuminuria (DM-MADM),123 DN complicated with chronic renal failure(DN-CRF) and the 125 healthy controls. Results: The allle C frequency in DM-MADM and DN-CRF was lower than that in DM and the control. There was no significant difference between DM and control group. The blood lipids and lipoproteins were not different between genotype SS and CC in every group. the odd ratio (OR) and 95% confidence interval (95%CI) of PON2 C311S caused DM complicated with nephropathy in DN-CRF was 2.68 (1.48-4.48), while in MADM was 2.63 (1.45-4.74).Conclusion:It is suggested that there are a relationship between allele C and DM complicated nephropathy in Zhengzhou Chinese population of han nationality." @default.
- W2368748922 created "2016-06-24" @default.
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- W2368748922 date "2008-01-01" @default.
- W2368748922 modified "2023-09-23" @default.
- W2368748922 title "The Relationship between Paraoxonase 2 C311S Gene Polymorphism and Type 2 Diabetes Mellitus Complicated with Nephropathy" @default.
- W2368748922 hasPublicationYear "2008" @default.
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