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- W2368758508 abstract "Acid isoferritin (AIF), a ferritin isomer with a high proposition of H subunit, is different from basic isoferritin (BIF) biochemically and immunologically. AIF was isolated and purified from human myocardium and the antiserum was obtained by immunizing the rabbits. A radioimmunoassay (RIA) of AIF and an immunora-diometric assay of AIF-H subunit were established by preparing 125I-AIF and 125I-AIF-H McAb using the chloramine-T method. The intra-and inter-assay CV of AIF RIA were 1. 65% and 9. 71%,respectively. The recovery rate was 102%. The antiserum provided a linear response from 7. 0-369. 6 ug/L, with ED50 of 27. 50 Hg/L. AIF-H IRMA methodological study found that the intra- and inter- assay CV were 2. 44% and 10. 16%, respectively. The sensitivity was 0. 74 ug/L, the recovery rate was 92. 29% and ED50 was 23. 05 ug/L. The cross-reactivity of the two assays with AFP, CEA and lactoferritin was negligible, while that with BIF was 1. 74% and 3. 13%, respectively. The serum AIF concentration showed a considerable variation in different sexes and age groups. Its sensitivity for diagnosis of hepatic cancer was 73. 05%, independent on the severity of hepatic injury. In eight kinds of malignant tumors studied, AIF was found to be most valuable in diagnosis of hepatic cancer, with its positive, negative, false-postive and fase-negative rates being all ideal. The patients with hepatoma had increased concentration of serum AIF-H subunit, so measuring the ratio of H/L subunits was valuable for studying the diseases. These results suggest that AIF may turn to be a rather specific index of hepatic cancer. Combination of monitoring both AIF and AFP would raise the rate of detection of positive cases and improve the specificity of method for the diagnosis of hepatic cancer." @default.
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- W2368758508 date "1997-01-01" @default.
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- W2368758508 title "RELATION BETWEEN HUMAN MYOCARDIAL ACIDIC ISOFERRITIN AND HEPATOMA" @default.
- W2368758508 hasPublicationYear "1997" @default.
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