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- W2368758963 abstract "Objective To investigate the expression of costimulatory molecules CD28,B7-1(CD80) and B7-2(CD86) on peripheral blood lymphocytes(PBLC)in patients with systemic lupus erythematosus(SLE) and its significance.To investigate if the costimulatory pathway in the patients with SLE is abnormal.Methods The expression of B7-1 and B7-2 on peripheral blood lymphocytes was measured by flow cytometric assay in 30 patients with SLE and 15 normal controls.Results There was no significantly difference of expression of B7-1 on PBLC between SLE patients with normal controls.Expression of B7-2 on PBLC in patients with SLE was significantly lower than that of normal controls(P0.01);Expression of CD28 on PBLC in patients with SLE was significantly lower than that of normal controls(P0.05).Conclusion The expression of B7-2 and CD28 on PBLC in SLE patients was decreased,which may impair the costimulatory pathway and be related to the pathogenesis of SLE." @default.
- W2368758963 created "2016-06-24" @default.
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- W2368758963 date "2007-01-01" @default.
- W2368758963 modified "2023-09-23" @default.
- W2368758963 title "A Correlation Study between the B_7-CD_(28) Costimulatory Pathway and Systemic Lupus Erythematosus" @default.
- W2368758963 hasPublicationYear "2007" @default.
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