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- W2368759700 abstract "Objective Using HB surface antigen(HBsAg) stimulated peripheral blood mononuclear cells(PBMCs) from low- and non-responders to hepatitis B vaccine,and investigated whether can induce a population of HBsAg specific CD4+CD25+ regulatory T cells.Methods PBMCs from low- and non-responders to hepatitis B vaccine were incubated in the presence of PHA and HBsAg.The frequencies of CD4+CD25+ regulatory T cells was determined by flow cytometry and lymphocyte proliferative respones was determined by MTT colorimetric assay.Results After stimulation with HBsAg,the frequencies of CD4+CD25+ regulatory T cells in low- and non-responders to hepatitis B vaccine were significantly high than after PHA stimulation and control(P0.01);but the Treg frequencies of three holes in hyper-responders displayed no difference statistically.The lymphocyte proliferative respones determined by MTT colorimetric assay showed that,after HBsAg stimulation the lymphocyte proliferative respones in low- and non-responders to hepatitis B vaccine were significantly low than those of hyper-responders(P0.01),but after PHA stimulation and control,the data of the three groups displayed no difference statistically.Conclusion Low- and non-responsiveness to hepatitis B vaccine are probobly because after injection of hepatitis B vaccine the HBsAg can induce a population of HBsAg specific CD4+CD25+ regulatory T cells and this population of T cells can inhibit immume response,so induce low- and non-responsiveness to hepatitis B vaccine." @default.
- W2368759700 created "2016-06-24" @default.
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- W2368759700 date "2008-01-01" @default.
- W2368759700 modified "2023-09-24" @default.
- W2368759700 title "Intruduction of CD4~+CD25~+ Regulatory T Cells by HBsAg from Peripheral Blood Mononuclear Cells in Low and Non-responders to Hepatitis B Vaccine in Vitro" @default.
- W2368759700 hasPublicationYear "2008" @default.
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