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- W2368762237 abstract "Objective To investigate the effects of high density lipoprotein cholesterol(HDL-C) and its related factors, apolipoprotein A-Ⅰ(apoA-Ⅰ) and serum amyloid A(SAA),on the non-diabetic patients with coronary heart disease(CHD).Methods One hundred and eighty consecutive patients were enrolled in this study,with 94 in CHD group and 86 in control group.The data on demography,lipid,and inflammation related factors were obtained from hospital records.Serum concentrations of apoA-ⅠI and SAA were measured by ELISA.The association of HDL-C,apoA-Ⅰand SAA with CHD was analyzed.Results There were more patients with hypertension,smoking,and early onset CHD history in CHD group than in control group.Compared with control group,the concentrations of triglyceride,lipoprotein,high-sensitivity C-reactive protein(hsCRP) and SAA were significantly higher in CHD group (P0.05),while concentrations of HDL-C(P=0.000) and apoA-Ⅰ(P=0.000) were significantly lower in control group(P0.05).Logistic analysis showed that the unadjusted odd ratio(OR) for HDL-C,apoA-Ⅰand SAA in the presence of CHD was 0.125(95%CI 0.039-0.397),0.012(95%CI 0.001-0.99) and 1.166(95%CI 1.054-1.291),respectively.The associations between apoA-Ⅰand the presence of CHD remained strong,regardless of confounding variables.The association of HDL-C and SAA with the presence of CHD were lost after adjusting for lipid status and inflammation related parameters.Conclusion Decreased concentration of apoA-Ⅰis an independent risk factor for non-diabetic CHD.Change in apoA-Ⅰconcentration can reflect the effects of HDL-C on CHD more accurately and effectively." @default.
- W2368762237 created "2016-06-24" @default.
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- W2368762237 date "2011-01-01" @default.
- W2368762237 modified "2023-09-24" @default.
- W2368762237 title "High density lipoprotein cholesterol and its associated factors apoA-I and serum amyloid A in non-diabetic patients with coronary heart disease" @default.
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