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- W2368762941 abstract "To study the characteristics of transient outward K~+current(I_(to)) and ultra-rapid delayed rectifier K~+current(I_(Kur)at different temperature in congestive heart failure(CHF)patients,I_(to)and I_(Kur)were recorded using whole-cell patch clamp technique.The Results showed that I_(to) and I_(Kur)had distinct activation or inactivation kinetic properties at different temperature.Compared with higher temperature,the activating thresholds of I_(to)and I_(kur)at lower temperature were lower,and the half-maximal activation potentials of I_(to)and I_(Kur) were smaller,however their Current-voltage relationships were not changed.The current densities of I_(to) were smaller when depolarized to +50 mV,and that of I_(Kur) were smaller either under identical voltage.But the voltage-dependent inactivation of I_(to)was not affected by temperature.Activation time constants or inactivation time constants of I_(to)were smaller at lower temperature,and the relationships of timevoltage were not modified obviously.However,they became greater when temperature rose,and decreased when potential increased.We could draw a conclusion from this experiment that I_(to)and I_(Kur)had different properties at 5—9℃and16-20℃." @default.
- W2368762941 created "2016-06-24" @default.
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- W2368762941 date "2014-01-01" @default.
- W2368762941 modified "2023-09-23" @default.
- W2368762941 title "Contributions of temperatures to I_(to) and I_(Kur) in human atrial myocytes isolated from patients with congestive heart failure" @default.
- W2368762941 hasPublicationYear "2014" @default.
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