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- W2368763452 abstract "Objective:To evaluate the objective anti-tumor efficacy and safety of sequential weekly dose of floxuridine (FUDR) with leucovorin, docetaxel, cisplatin contrast with ECF regimen for advanced gastric cancer. Methods:Fifty-six cases of advanced gastric cancer were divided into 2 groups, LFTP group and ECF group. LFTP group used CF 100mg iv d1,d8,d15, FUDR 500mg/m2 iv d1,d8,d15, docetaxel 35mg/m2 iv d2,d9,d16, cisplatin 30mg/m2 iv d3,d10,d17. ECF group used CF 100mg iv d1-d5, 5-FU 500mg/m2 iv d1-d5, EPI 50mg/m2 iv d2, cisplatin 30mg/m2 iv d3,d4,d5, this regimen was repeated every 4 weeks. All the patients were received 2 cycles. Results:LFTP group: 59.3%(16/27)of response rate were achieved with PD 7.4%(2/27),in all 27 cases; ECF group: 51.7%(15/29) (P=0.181 4) of response rate were achieved with PD 34.5%(10/29) (P=0.012 6) in all 29 cases. The major toxicity included mucositis, diarrhea, phlebitis, nausea vomiting, neutropenia. Among side effects mucositis was the most common seen. Most were grade Ⅰ-Ⅱ which were tolerable for all patients. Conclusion:The regimen was an effective chemotherapy for advanced gastric cancer, the adverse reactions were not severe, further clinical study should be warranted." @default.
- W2368763452 created "2016-06-24" @default.
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- W2368763452 date "2007-01-01" @default.
- W2368763452 modified "2023-09-26" @default.
- W2368763452 title "Clinical study of sequential weekly dose of 5-fluoro-2'-deoxyuridine with leucovorin, docetaxel, cisplatin contrast with ECF regimen for advanced gastric cancer" @default.
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