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- W2368764236 abstract "AIM To set up a LC-ESI-MS/MS method for palonosetron assay in human plasma.METHODS Palonosetron was extracted with ethyl acetate-dichloromethane.The residues were analyzed with a LC-ESI-MS/MS system (Agilent TC C_(18) column,150 mm×4.6 mm,5μm) with the mobile phase consisted of acetonitrile with 0.04 mol·L~(-1) ammonium formate(0.04%formic acid)=80:20(V/V).The Agilent 6 410 triple quad mass spectrometer system equipped with an electrospray ionization ion-trap source was used as the detector and operated in the positive ion mode. Selected reaction monitoring(SRM) by using precursor to produce ion combinations of m/z 297.2→82.2 and m/z 285.l→154.0 was performed to detect palonosetron and the internal standard,respectively.RESULTS The average extraction recoveries for palonosetron were 78.86%,78.35%and 80.15%.respectively.The within-day(n=5) and between-day(n=3) precision of variation was less than 15%.The calibration curve for palonosetron was linear within the range of 0.05-10μg·L~(-1).The limit of quantitation for palonosetron was 0.05μg·L~(-1).CONCLUSION The method provides a sensitive,accurate,simple and rapid analytical procedure for clinical monitoring of palonosetron and its phamacokinetic studies." @default.
- W2368764236 created "2016-06-24" @default.
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- W2368764236 date "2009-01-01" @default.
- W2368764236 modified "2023-09-25" @default.
- W2368764236 title "Rapid determination of palonosetron in human plasma by LC-ESI-MS/MS" @default.
- W2368764236 hasPublicationYear "2009" @default.
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