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- W2368767569 abstract "Objective To investigate the relationship between the chemotherapeutic effect on brain tumors and the enhancement effect of its MRI.Methods Retrospectively analyze 131 patients with brain tumors,which were divided into two groups as primary and metastatic tumors by the diagnosis,non-enhancement and enhancement effect by the brain MRI,lipophil and hydrophil by the treatment regimen.The therapeutic effect was classified as CR,PR,SD and PD conventionally.The relationship between the chemotherapeutic effect on brain tumors and the enhancement of their MRI was analyzed with statistical software SPSS 17.0.Results In 39 patients with primary brain tumors,there were 23 patients with non-enhancement MRI,and 2 of them achieved PR,both of whom came from lipophilic regimen;there were 16 patients with enhancement MRI with 7 effective (CR+PR).There were significant difference between the two groups(χ2=6.532,P=0.011).In the patients with enhancement MRI,the effective rate of lipophilic regimen and hydrophilic regimen was 44.4%(4/9) and 42.9%(3/7) respectively,the difference was not significant(χ2=0.004,P=0.949).In 92 patients with metastatic tumors,there were 9 patients with non-enhancement MRI,and only 1(11.1%) achieved PR;on the other hand,49 of 83(59.0%) patients with enhancement MRI achieved CR or PR.In those patients with enhancement MRI,the effective rate of lipophilic regimen and hydrophilic regimen was 33.3%(2/6)and 61.0%(47/77) respectively,and the difference was not significant(χ2=1.767,P=0.184).In aggregate analysis,the effective rate in patients with non-enhancement MRI was 9.4%(3/32),while 56.6% in enhancement patients;the overall efficiency of lipophilic regimen and hydrophilic regimen were 0 and 59.5% respectively.Conclusion The effects of chemotherapy in patients with brain tumors are highly concordant with the enhancement effect of their MRI.The enhancement effect of MRI indicates a deprivation of blood-brain barrier (BBB),thus the hydrophilic agents can be applied to treatment either primary brain tumor or brain metastases derived from systematic tumor." @default.
- W2368767569 created "2016-06-24" @default.
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- W2368767569 date "2010-01-01" @default.
- W2368767569 modified "2023-09-22" @default.
- W2368767569 title "A Relationship Analysis between the Chemotherapeutic Effect on Brain Tumor and Their Enhancement MRI" @default.
- W2368767569 hasPublicationYear "2010" @default.
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