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- W2368767784 abstract "Objective: To investigate effect of docosahexaenoic acid (DHA) on gene expression profiles of human dendritic cells. Methods: Dendritic cells were generated from human peripheral blood monocytes in the presence of GM-CSF and IL-4, and then treated with DHA (50 μmol/L) for 24h. Lipopolysaccharide(100 ng/ml) was used for maturation of dendritic cells. Gene expression of different dendritic cells was analyzed by cDNA microarray technology . Results of gene array were verified by RT-PCR. DCs treated with stearic acid(SA) were served as control groups. Results: A total of 20 genes exhibited differential expression in DHA-treated dendritic cells compared with control. Eighteen genes were up-regulated and two genes were down-regulated,which included cytokines, chemokines, chemokine receptors and antigen presentation molecules. Conclusions: DHA has significant suppressive effects on dendritic cells in their maturation procession and the changed pattern is related to cytokines, chemokines, chemokines receptors and antigen presentation molecules." @default.
- W2368767784 created "2016-06-24" @default.
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- W2368767784 date "2005-01-01" @default.
- W2368767784 modified "2023-09-26" @default.
- W2368767784 title "Effect of docosahexaenoic acid on gene expression profiles of human dendritic cells" @default.
- W2368767784 hasPublicationYear "2005" @default.
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