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- W2368790744 abstract "Objective To detect the expression of human papillomavirus type 16 E7 protein(HPV16 E7),transforming growth factor β1(TGF β1) and membrane type-1 matrix metalloproteinase(MT1-MMP) in human cervical neoplasms and explore their possible roles in tumor formation and progression. Methods Immunohistochemical staining technique was used to detect the expressions of HPV16 E7,TGF β1 and MT1-MMP in 64 paraffin embedded samples of different cervical lesions. Results In the progression from benign to malignant,the expressions of TGF β1 and MT1-MMP increased significantly(P0.05).In HPV16 E7 positive group,the expressions of TGF β1 and MT1-MMP were higher than the HPV16 E7 negative group(P0.01).The association between TGF β1 and MT1-MMP expression was significant(r=0.96,P0.01). Conclusion The expressions of TGF β1 and MT1-MMP are related to whether or not the lesion of cervix is malignant,a higher expression of them is one of the manifestations suggesting of malignancy.HPV16 infection may affect the expression of TGF β1 and MT1-MMP through E7 protein." @default.
- W2368790744 created "2016-06-24" @default.
- W2368790744 creator A5048935008 @default.
- W2368790744 date "2008-01-01" @default.
- W2368790744 modified "2023-09-23" @default.
- W2368790744 title "EXPRESSION OF HUMAN PAPILLOMAVIRUS TYPE 16 E7,TRANSFORMING GROWTH FACTOR β1 AND MEMBRANE TYPE-1 MATRIX METALLOPROTEINASE IN DIFFERERNT STAGES OF HUMAN CERVICAL LESIONS" @default.
- W2368790744 hasPublicationYear "2008" @default.
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