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- W2368802846 abstract "OBJECTIVE To investigate the differential protein expression during apoptosis induced by tea polyphenol-manganese(TP-Mn) in HepG2 cells.METHODS HepG2 cells were exposed to TP 700 mg·L-1,TP-Ge 700 mg·L-1 and TP-Mn 700 mg·L-1 for 48 h,respectively.Morphologic changes in HepG2 cells were tested by optical microscope,the number of apoptosis rates were analyzed by flow cytometry,and the differential proteins were identified by peptide mass fingerprinting(PMF).RESULTS Optical microscope examination revealed that the number of HepG2 cells was significantly reduced in TP and TP-Mn groups;the cells appeared shrunken and deformed,and these were dead cells.However,the number of HepG2 cells was not significantly reduced in TP-Ge group.The apoptosis rate of HepG2 cells in TP-Mn group was(30.1±0.7)%,which was significantly higher than in TP group(12.3±0.4)%(P0.05) revealed by flow cytometry.2D-PAGE showed that multiple differential proteins could be expressed in HepG2 cells during apoptosis induced by TP-Mn.Peptide mass fingerprinting and database searching showed that γ-actin and tyrosine 3-/tryptophan 5-monooxygenase activation proteins were of high score matching.CONCLUSION TP-Mn can induce HepG2 cell apoptosis,and multiple differential proteins can be expressed in HepG2 cells during the apoptosis." @default.
- W2368802846 created "2016-06-24" @default.
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- W2368802846 date "2011-01-01" @default.
- W2368802846 modified "2023-09-22" @default.
- W2368802846 title "Differential protein expression during apoptosis induced by tea polyphenol-manganese in human hepatoma cells" @default.
- W2368802846 hasPublicationYear "2011" @default.
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