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- W2368804434 abstract "Poly(ADP-ribose) polymerase(PARP) represents a currently important target in cancer therapy,which is essential to the repair of single strand DNA breaks via the base excision repair pathway.Inhibitors of PARP have been in clinical trials with multiple indications.Recently,clinical data suggested that PARP inhibitors could be used not only as chemo/radiotherapy sensitizers,but also as single agents to selectively kill cancers that are defective in DNA repair,particularly cancers with mutations in the breast cancer associated BRCA1/2 genes.This review summarized the mechanism of PARP inhibitors and current clinical data of five most important PARP inhibitors." @default.
- W2368804434 created "2016-06-24" @default.
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- W2368804434 date "2014-01-01" @default.
- W2368804434 modified "2023-09-28" @default.
- W2368804434 title "Progress in research of drugs targeting PARP for cancer therapy" @default.
- W2368804434 hasPublicationYear "2014" @default.
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