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- W2368809452 abstract "Objective To investigate the effects of matrine on insulin to promote cardiac fibroblast(CF)proliferation and collagen synthesis in rats. Methods From November 2011 to April 2012,digestion method was used to culture cardiac fibroblasts of SD rats. There were five groups in this experiment:① control group,managed with culture fluid;② insulin group,with insulin(final concentration 10- 8mol·L- 1);③low dose Mat + Ins group,with 0. 1mmol·L- 1Mat + Ins; ④ middle dose Mat + Ins group,with 0. 2mmol·L- 1Mat + Ins;⑤high dose Mat + Ins group,with 0. 4mmol·L- 1Mat + Ins. CF proliferation was measured by thiazolyl blue( MTT) assay( A490),and collagen synthesis by 3H- thymidine(3H-TdR) uptake test. The effects of matrine on insulin to promote CF proliferation and collagen synthesis were observed,as well as the action of different concentrations of Mat against CF proliferation and collagen synthesis. Results As Mat concentration increased,CF A490 value showed a decreasing trend. It was(0. 140 ±0.026) and(0. 089 ±0. 005) respectively in middle and high dose Mat + Ins groups,which were significantly lower than that in control group(0. 323 ± 0. 097, P 0. 05). A490 value in low,middle and high dose Mat + Ins groups was significantly lower than that in Ins group( P 0. 05). With the increasing of Mat concentration,the rate of 3H- TdR incorporation into CF showed a decreasing trend. It was(655. 96 ± 52. 57) and(376. 14 ± 56. 33) respectively in middle and high dose Mat + Ins groups,which were significantly lower than that in control group(1 326. 32 ± 278. 03,P 0. 05). The rate of 3H- TdR incorporation into CF was lower in low,middle and high dose Mat + Ins groups than in Ins group(P 0. 05). Conclusions Insulin can promote CF proliferation and collagen synthesis in vitro,which can be inhibited by Mat. This action of Mat is dose- dependent." @default.
- W2368809452 created "2016-06-24" @default.
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- W2368809452 date "2013-01-01" @default.
- W2368809452 modified "2023-09-26" @default.
- W2368809452 title "Effects of matrine on insulin to promote cardiac fibroblastproliferation and collagen synthesis in rats" @default.
- W2368809452 hasPublicationYear "2013" @default.
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