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- W2368825332 abstract "CGA-N46 is a novel antifungal peptide derived from human chromogranin A.The study was designed to evaluate its curative effect on the skin infection of mice.The skin infection model of mice infected with Candida krusei was set up successfully after being checked by skin symptom and C.krusei isolated from scurf and coats.The CGA-N46 at two different concentrations,4mg/mL and 8mg/mL CGA-N46,were applied for treatment respectively.The survival rate and the relieving rates were calculated,and the skin pathological lesions with HE staining were observed.The results showed that the lowest concentration of infection with Candida krusei was 2×108 CFU/mL;CGA-N46 could increase the survival rate of C.krusei-infected mice,and relieve the infection symptoms at a dose-dependent pattern.In conclusion,CGA-N46 had commendable curative effect on clinical infection of C.krusei and had potency to be a novel antifungal drugs." @default.
- W2368825332 created "2016-06-24" @default.
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- W2368825332 date "2015-01-01" @default.
- W2368825332 modified "2023-09-23" @default.
- W2368825332 title "Curative Effect of Antifungal Peptide CGA-N46 on the Skin of Mice Infected with Candida krusei" @default.
- W2368825332 hasPublicationYear "2015" @default.
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