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- W2368831452 abstract "Objective To investigate the inhibition of deuterium-depleted water (DDW) in the proliferation and invasion of HepG2 cells. Methods HepG2 cells and normal heptocytes LO2 were treated with 50, 75, 100, 150 ppm DDW (pure water, control group). The proliferation, invasiveness and PCNA expression of HepG2 and LO2 cells were determined using MTT, plate cloning assay and Western blot, respectively. Results Proliferation of LO2 cells and HepG2 cells showed no change after 24 h and 72 h of 100 ppm DDW treatment (P0.05), respectively. Compared with control group, colony formation decreased in HepG2 cells but increased in LO2 cells after incubation with 50, 75 ppm DDW (P0.01), and PCNA expression of HepG2 cells reduced significantly after treatment with 50,75,100 ppm DDW (P0.01). Conclusion DDW can inhibit the proliferation and invasion of HepG2 cells but reinforce the growth of LO2 cells, which may be related to the PCNA downexpression." @default.
- W2368831452 created "2016-06-24" @default.
- W2368831452 creator A5014330983 @default.
- W2368831452 date "2013-01-01" @default.
- W2368831452 modified "2023-09-26" @default.
- W2368831452 title "Deuterium-depleted water inhibits proliferation and invasion of HepG2 cells" @default.
- W2368831452 hasPublicationYear "2013" @default.
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