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- W2368846543 abstract "Objective To evaluate the effect of sustained-release polymer containing dexamethasone(Dex) in the brain for the reduction of brain edema and nitric oxide synthase(NOS) activity.Methods Cold injury was induced by applying a copper probe cooled with liquid nitrogen on the left hemisphere of each rat to form brain edema,then polymer containing Dex or not was implanted into the brain.Twenty-four hours later,all animals were sacrificed to determine NOS concentration and water content of brain,respectively.Results In the groups treated with sustained-release polymer containing Dex,the NOS activity [(11.50 ± 2.41) U/ml] dropped contrasting with the injuried group [(15.84 ± 3.74) U/ml] and the water content(80.93% ± 2.27%) was lower than that of the control group(85.54% ± 2.69%).No significant differences were found on NOS activity and water content levels between interstitial delivery and intraperitoneal injection groups[(12.55 ± 2.66) U/ml,81.29% ± 2.22%).Conclusion The results suggest that the protective effects of the polymer containing Dex and intraperitoneal Dex injection against brain edema were similar.Brain edema can be effectively controlled by the polymer and the mechanism may be associated with the depression of NOS activity." @default.
- W2368846543 created "2016-06-24" @default.
- W2368846543 creator A5049087540 @default.
- W2368846543 date "2005-01-01" @default.
- W2368846543 modified "2023-09-23" @default.
- W2368846543 title "The effect of interstitial delivery of dexamethasone on brain edema and nitric oxide synthase activity" @default.
- W2368846543 hasPublicationYear "2005" @default.
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