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- W2368852023 abstract "Objective To establish the animal model of acute hibernating myocardium(AHM) by the method of closed-chest, observe the changes of QT dispersion(QTd) of AHM and the effect of dobutamine on QTd of AHM, investigate the clinical significance. Methods 13 little domestic Chinese swine were established to the model of AHM by interventional method (closed-chest),RCA was target vessel, standard dobutamine stress echocardiography(DSE,0-40 μg·Kg-1·min-1) were performed to detect hibernating myocardium. After reperfusion successfully, animals were killed, the heart was stained with TTC and the histomography changes of AHM cells were assessed by microscope. QTd were observed throughout the course. Results (1)10 animals(76.92%)were established to the model of AHM successfully, myocardium necrosis were not found.(2)QTd increased significantly in AHM model[(68.75±5.33)ms vs (25.00±1.77)ms,P0.05=,and decreased obviously after reperfusion successfully[(35.62±3.47)ms vs (68.75±5.33)ms,P0.05=. There was no difference between normal status and reperfusion[(35.62±3.47)ms vs (25.00±1.77)ms,P0.05]. (3)During DSE, QTd appeared as the trend of biaphasic response.(4)QTd of AHM correlated to the amounts of AHM segments negatively(r=-0.64,P0.05=. Conclusion (1)QTd of AHM increased significantly, it decreased obviously after early reperfusion successfully. (2)During DSE, QTd appeared as the trend of biaphasic response. (3)QTd may be a valuable index which can reflect the amounts of hibernating myocardium." @default.
- W2368852023 created "2016-06-24" @default.
- W2368852023 creator A5034513446 @default.
- W2368852023 date "2006-01-01" @default.
- W2368852023 modified "2023-09-24" @default.
- W2368852023 title "Experimental study of the effect of dobutamine stress test on QT dispersion of acute hibernating myocardium" @default.
- W2368852023 hasPublicationYear "2006" @default.
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