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- W2368852048 abstract "Human DSCR1 gene is located in Down syndrome critical region on chromosome 21.The DSCR1 expressed extensively in body such as breast,uterus,skin,fetus,lung,liver and pancreas that distributed with different degree.Now,there is growing evidence that DSCR1 is involved in not only Down syndrome but also Alzheimer's disease.However,we know little about its detailed roles in these diseases so far.In this work,to synthesize the differential immunogenic peptide,then the purified peptide was coupled to the hemocyanin from Keyhole Limpets(KLH).The peptide-KLH solution was mixed with freund's complete or incomplete adjuvant and immunized rabbit to prepare specific polyclonal antibody against the N-terminus 5570 amino acids segment of DSCR1 large isotype.Western blotting analysis and immunoprecipitation suggested that the polyclonal antibody recognize the DSCR1 protein in murine brain and heart.DSCR1 protein was ubiquitously modified by the experiment of dealing Hela cells with MG132.So the DSCR1 may be involved in ubiquitin-proteosome pathway.Then we developed co-immunoprecipitation combined DSCR1 polyclonal antibody with ubiquitin polyclonal antibody to detect murine brain tissue.The result suggested that DSCR1 protein in mouse brain had ubiquitous modification indeed." @default.
- W2368852048 created "2016-06-24" @default.
- W2368852048 creator A5048839577 @default.
- W2368852048 date "2006-01-01" @default.
- W2368852048 modified "2023-09-28" @default.
- W2368852048 title "DSCR1 may be Participated in Ubiquitin-proteosome Pathway" @default.
- W2368852048 hasPublicationYear "2006" @default.
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