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- W2368854427 abstract "Objective To detect the relationship between peripheral insulin resistance and islet β cell function in obese subjects with normal blood glucose.Methods The Botnia clamp,that is an intravenous glucose tolerance test followed by a euglycemic-hyperinsulinemic clamp,was performed in 15 normal subjects and 15 cases of obesity with normal glucose tolerance.The rate of insulin-mediated glucose disposal(Rd)during the steady state of glucose clamp was used to assess the peripheral tissue insulin sensitivity.The disposition index(DI)is a measure of insulin secretion adjusted for insulin sensitivity and was calculated from the product of the FPIR and the Rd.Results Obese patients showed decreased Rd(P=0.009),but similar FHR,compared with Healthy people.However,the DI was significantly impaired(P=0.011).The Rd was significantly correlated negatively with free fatty acids(FFA)(r=-0.528,P=0.003).FPIR was significantly correlated negatively with the uric acid(UA)and FFA(r=-0.431,P=0.017;r=-0.473,P=0.008).Conclusion The present data showed that in obese subjects with normal blood glucose,there were severe peripheral insulin resistance,relative deficiency of cell first-phase insulin release.It is logical to deduce that both insulin resistance and the cell changes could be,at least partially,secondary to high levels of serum FFAs." @default.
- W2368854427 created "2016-06-24" @default.
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- W2368854427 date "2010-01-01" @default.
- W2368854427 modified "2023-09-23" @default.
- W2368854427 title "The clinic evaluation of insulin resistance and lislet β cell function in obese subjects with normal blood glucose." @default.
- W2368854427 hasPublicationYear "2010" @default.
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