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- W2368863051 abstract "【Objective】 To investigate induction of apoptosis by 5,7-dimethoxyflavone(5,7-DMF) in human lung cancer A549 cells and its mechanism.【Methods】 Human lung cancer A549 cells line was cultured in vitro.The inhibitory effect of 5,7-DMF on the viability of human lung cancer A549 cells was measured by MTT assay.The apoptotic rate of A549 cells treated with 5,7-DMF was analyzed by Flow cytometry with annexin V/PI fluorescence staining.The cell mitochondrial membrane potential was detected by Flow cytometry using the probe of JC-1.Cytochromes-c release of mitochondrion and Bax protein expression were analyzed by Western Blotting.【Results】 The MTT assay showed that 5,7-DMF significantly inhibited the viability of A549 cells in a concentration-dependent manner.The Flow cytometry with annexin V/PI fluorescence staining indicated that the apoptotic rates of A549 cells treated with 10μmol/L 5,7-DMF for 6 h,12 h,24 h were(6.58±0.65)%,(16.70±1.85)%,(28.60±3.52)%,respectively.The Flow cytometry with the probe of JC-1 indicated that 5,7-DMF caused collapse of mitochondrial membrane potential in A549 cells.The results of Western Blotting demonstrated that the cytochromes-c release of mitochondrion increased,and the expression of Bax up-regulated.【Conclusion】 5,7-DMF inhibits the viability and induces apoptosis of A549 cells,which may be associated with activation of mitochondrial apoptotic pathway." @default.
- W2368863051 created "2016-06-24" @default.
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- W2368863051 date "2011-01-01" @default.
- W2368863051 modified "2023-09-28" @default.
- W2368863051 title "5,7-dimethoxyflavone induction of apoptosis of human lung cancer A549 cell line through mitochondrial pathway" @default.
- W2368863051 hasPublicationYear "2011" @default.
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