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- W2368864023 abstract "Objective:To study the cellular immune responses in mice immunized with the vector expressing E2 protein and find out whether the ability of inducing cellular immunity by E2 gene immunization was affected by HBV preS gene when they were fused. Methods: The target cells were established by transfecting the vector expressing HCV E2 protein into SP 2/O myeloma cells from BALB/c mice, and then injected into the abdominal activity of the mice immunized with HCV E2 gene. The cellular immune response of the E2 gene immunized mice to HCV E2 protein was presented by its survival time after injected target cells. Results: The molecular weight of the HCV E2 protein expressed in the target cell was about 70 000. After injected target cells, the average survival time of the mice in the group immunized with E2 gene alone was longer than that of the group injected with E2 gene fused with HBV preS and was significantly longer than that of the control. Conclusion: Cellular immune responses to HCV E2 protein could be induced by injecting the vector expressing E2 protein into mice, but the ability of E2 gene inducing cellular immunity was reduced when fused with HBV preS. ( J Beijing Med Univ, 2000,32:102 104 )" @default.
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- W2368864023 date "2000-01-01" @default.
- W2368864023 modified "2023-09-25" @default.
- W2368864023 title "Study of the cellular immune responses in mice immunized with DNA vector encoding hepatitis C virus E2 protein" @default.
- W2368864023 hasPublicationYear "2000" @default.
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