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- W2368866444 abstract "Objective:The Bezold-Jarisch reflex(BJR) is one of the main causes for vasovagal syncope(VVS).Blocking the efferent pathways of the vagus ganglia in the heart may attenuate the BJR.Our study aimed to observe the effect excising the third fat pad(SVC-AO FP) during the veratridine-induced BJR in dogs.Methods: Right thoracotomy was performed in 30 mongrel dogs to access the chest cavities.The animals were divided into a control group and an intervention group,and the latter underwent excision of the superior vena cava-aortic fat pad(SVC-AO FP).Veratridine was injected into the left ventricle in bolus doses of 15μg/kg through a catheter to induce BJR.The heart rate(HR),systolic arterial pressure(SAP),diastolic arterial pressure(DAP),mean arterial pressure(MAP),left ventricle systolic pressure(LVSP),left ventricle diastolic pressure(LVDP) and left ventricular peak systolic and diastolic velocity(±dp/dtmax) were measured before and after veratridine injection.Results: There were no significant differences in the baseline values of HR,SAP,DAP,MAP,LVSP,LVEDP and ±dp/dtmax between the two groups(P0.05) before veratridine injection.The maximum decrement of HR was significantly lower in the intervention group than in the control(25.2±9.1bpm vs 93.3±18.4bpm,P0.01) after veratridine injection,but the maximum decrement of SAP,DAP,MAP,LVSP,LVEDP,+dp/dtmax and-dp/dtmax showed no significant differences between both groups(P0.05).Conclusion: Excision of the SVC-AO FP could significantly reduce bradycardia in veratridine-induced BJR." @default.
- W2368866444 created "2016-06-24" @default.
- W2368866444 creator A5074401541 @default.
- W2368866444 date "2009-01-01" @default.
- W2368866444 modified "2023-09-27" @default.
- W2368866444 title "Excising SVC-AO fat pads attenuates Bezold-Jarisch reflex in dogs" @default.
- W2368866444 hasPublicationYear "2009" @default.
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