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- W2368870440 abstract "Matrix metalloproteinase-9(MMP-9)is a kind of enzyme which can contribute to the atherosclerotic plaque formation,progression and rupture by degrading extracellular matrix.It is increased in the patients with atherosclerosis.Hyperglycemia can induce its expression and it is increased significantly in the type 2 diabetic patients with atherosclerosis.So reducing its levels,improving the remodeling of extracellular matrix have become the important therapeutic measurement in type 2 diabetes.Proxisome proliferator-activated receptor-gamma(PPARγ) is the member of nuclear receptor superfamily.It modulates the transcription of target genes,has antiatherosclerotic effects in many aspects.A key aspect is to inhibit the expression of MMP-9.PPARγ agonist(thiazolidinedione) can not only reduce blood glucose,blood lipids,improve insulin resistance,but also inhibit the production of MMP-9 and the formation and progression of atherosclerosis in type 2 diabetic patients." @default.
- W2368870440 created "2016-06-24" @default.
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- W2368870440 date "2006-01-01" @default.
- W2368870440 modified "2023-09-26" @default.
- W2368870440 title "Matrix metalloproteinase-9,PPARγ and atherosclerosis of type 2 diabetes" @default.
- W2368870440 hasPublicationYear "2006" @default.
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