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- W2368872078 abstract "Objective To investigate the relationship of the amplification and gene expression of Epidermal growth factor receptor ( EGFR) with the clinical pathology of glioma and tumor apoptosis activity. Methods The amplification and gene expression of EGFR in 10 normal brain tissue ,60 primary gliomas of different degrees and 25 Secondary glioma were studied by immunohistochemical staining,western blot analysis and filter in situ hybridization ( FISH) . The relationship between expression level of EGFR and apoptosis activity in glioma ( by detecting the expression of P53,a protein associated with apotosis) was studied. Results The amplification and gene expression of EGFR were different from glioma degree. EGFR expression was significantly increased in ascending order from low to high grade glioma( P 0. 05) . The rate of EGFR-immunohistochemical staining ( EGFR-IHC ) and EGFR-FISH was 85% and 40% in primary glioma,and it was 28% and 28% in secondary gliomas ( P 0. 05) . The results of FISH analysis of EGFR expression were not coincident with that of immunohistochemical staining. The primary glioblastoma cases with EGFR gene amplification were also with EGFR overexpression but only 31. 03% EGFR geneamplification in the cases of EGFR overexpression. It was positively correlated between expression of EGFR and P53 ( r = 14. 22,P = 0. 001 ) . Conclusions Expression and amplification level of EGFR has significantly different in different degree glioma,and it related to tumor cell apoptosis. The state of EGFR gene amplification was different in primary and secondary glioblastoma. EGFR may be a treatment target in glioblastoma treatment in future." @default.
- W2368872078 created "2016-06-24" @default.
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- W2368872078 date "2012-01-01" @default.
- W2368872078 modified "2023-09-23" @default.
- W2368872078 title "The relationship of the amplification and gene expression of EGFR with the clinical pathology of glioma and tumor apoptosis activit" @default.
- W2368872078 hasPublicationYear "2012" @default.
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