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- W2368873021 abstract "Objective: To investigate the effects of Valsartan (angiotensin Ⅱtype 1 receptor antagonist) on neointimal proliferation and expressions of Fas and Fas-L after balloon angioplasty in rabbits. Methods: Twenty-four male New Zealand white rabbits were randomly divided into three groups including the control group fed up with common diet,the model group and the valsartan group fed up with hypercholesterolemic diet. Ballon angioplasty was performed after 4 weeks. The model group was fed up with common diet and the valsartan group was fed up with the admixture of valsartan (10 mg·kg-1·d-1) and common diet during the following 4 weeks after the operation. Abdominal aorta was examined by pathologic and morphologic analysis and expressions of Fas and Fas-L were analyzed by immunohistochemical method 12 weeks later. Results: Compared with the model group,the neointimal thickness and area decreased by 56.58% and 66.81% in valsartan group. The expressions of Fas and Fas-L increased significantly in valsartan group (P 0.01). Conclusion: Valsartan has an inhibiting effect on neointimal proliferation of abdominal aorta in rabbits after balloon injury. The increasing levels of Fas and Fas-L and the promotion of the apoptosis of vascular smooth muscle cells might be the mechanism." @default.
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- W2368873021 date "2007-01-01" @default.
- W2368873021 modified "2023-09-28" @default.
- W2368873021 title "Effects of Valsartan on Neointimal Proliferation and Expressions of Fas and Fas-L after Balloon Angioplasty in Rabbits" @default.
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