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- W2368877401 abstract "AIM: To investigate the antioxidative activity of the ethanol and water extracts of Lycium barbarum and their dose-effect relationship. METHODS: The Lycium barbarum extracts were provided by our laboratory. Sprague-Dawley rats were killed and then the livers were harvested to isolate the microsomes by calcium precipitation. The oxidant-scavenging potential of the water and alcohol extracts was measured using the following chemiluminescence systems: CoCl2/EDTA-induced luminol chemiluminescence method and xanthine-xanthine oxidase-luminol method. Two types of lipid peroxidation of rat liver microsomes models were used to determine the antioxidation of Lycium barbarum extracts. Then the content of malondialdehyde (MDA) was tested by colorimetry for analyzing the antioxidation of Lycium barbarum extracts in the 2 models. RESULTS: In the 2 chemiluminescence systems, compared with control group, the inhibition rate of ·OH and O2-· by different dosages of the 2 extracts significantly increased(P0.01),and there was a linear dose-effect relationship between Lycium barbarum and luminous intensity; the IC50 of water extract was 1.22 and 3.12, and that of ethanol extract was 1.03 and 1.92. In the VC/Fe2+, CHP model, the content of MDA in those groups with different dosages of the 2 extracts significantly decreased(P0.01),and there was a dose-effect relationship between the final concentration and the inhibition rate of MDA. CONCLUSION: The two extracts of Lycium barbarum have effective antioxidative effects in a dose-effect relationship. But the ethanol extract has a comparatively stronger effect." @default.
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- W2368877401 date "2007-01-01" @default.
- W2368877401 modified "2023-09-24" @default.
- W2368877401 title "Antioxidation of Lycium barbarum extracts" @default.
- W2368877401 hasPublicationYear "2007" @default.
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