Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368878052> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2368878052 abstract "AIM To study the effects of strophanthidin (Str) on cardiac function and Na +,K +-ATPase activity in isolated guinea pig heart failure model. METHODS Langendorff isolated heart failure models made by perfusing heart with K-H solution containing sodium pentobarbital. Eight-channel physiological recording instrument was used to determine cardiac function. Colorimetry method was used to determine cardiac sarcolemmal Na +,K +-ATPase activity. RESULTS Str increased the heart rate, left ventricular systolic pressure and the maximum rise or decline rate of left ventricular pressure in a concentration-dependent manner at 1×10 -9～1×10 -7 mol·L -1. But Str caused first a rise, then a reduction of contractility and arrhythmia accompanied by inhibition of Na +,K +-ATPase when the concentration of Str was higher than 1×10 -6 mol·L -1. Str had no obvious effect on Na +,K +-ATPase activity at 1×10 -7 mol·L -1, but increased cardiac activity at 1×10 -10～1×10 -8 mol·L -1. CONCLUSION The inotropic effect and heart toxicity of Str at higher concentration is due to inhibition of Na +,K +-ATPase, but the inotropic effect of Str at lower concentration is not the result of inhibition of Na +,K +-ATPase activity." @default.
- W2368878052 created "2016-06-24" @default.
- W2368878052 creator A5043000891 @default.
- W2368878052 date "2003-01-01" @default.
- W2368878052 modified "2023-09-25" @default.
- W2368878052 title "Effect of low concentrations of strophanthidin on isolated guinea pig failure hearts" @default.
- W2368878052 hasPublicationYear "2003" @default.
- W2368878052 type Work @default.
- W2368878052 sameAs 2368878052 @default.
- W2368878052 citedByCount "0" @default.
- W2368878052 crossrefType "journal-article" @default.
- W2368878052 hasAuthorship W2368878052A5043000891 @default.
- W2368878052 hasConcept C111566952 @default.
- W2368878052 hasConcept C126322002 @default.
- W2368878052 hasConcept C134018914 @default.
- W2368878052 hasConcept C155710745 @default.
- W2368878052 hasConcept C178790620 @default.
- W2368878052 hasConcept C181199279 @default.
- W2368878052 hasConcept C185592680 @default.
- W2368878052 hasConcept C23265538 @default.
- W2368878052 hasConcept C26635844 @default.
- W2368878052 hasConcept C2776755955 @default.
- W2368878052 hasConcept C2777953023 @default.
- W2368878052 hasConcept C2778198053 @default.
- W2368878052 hasConcept C2778815084 @default.
- W2368878052 hasConcept C39133596 @default.
- W2368878052 hasConcept C537181965 @default.
- W2368878052 hasConcept C55493867 @default.
- W2368878052 hasConcept C71924100 @default.
- W2368878052 hasConcept C84393581 @default.
- W2368878052 hasConceptScore W2368878052C111566952 @default.
- W2368878052 hasConceptScore W2368878052C126322002 @default.
- W2368878052 hasConceptScore W2368878052C134018914 @default.
- W2368878052 hasConceptScore W2368878052C155710745 @default.
- W2368878052 hasConceptScore W2368878052C178790620 @default.
- W2368878052 hasConceptScore W2368878052C181199279 @default.
- W2368878052 hasConceptScore W2368878052C185592680 @default.
- W2368878052 hasConceptScore W2368878052C23265538 @default.
- W2368878052 hasConceptScore W2368878052C26635844 @default.
- W2368878052 hasConceptScore W2368878052C2776755955 @default.
- W2368878052 hasConceptScore W2368878052C2777953023 @default.
- W2368878052 hasConceptScore W2368878052C2778198053 @default.
- W2368878052 hasConceptScore W2368878052C2778815084 @default.
- W2368878052 hasConceptScore W2368878052C39133596 @default.
- W2368878052 hasConceptScore W2368878052C537181965 @default.
- W2368878052 hasConceptScore W2368878052C55493867 @default.
- W2368878052 hasConceptScore W2368878052C71924100 @default.
- W2368878052 hasConceptScore W2368878052C84393581 @default.
- W2368878052 hasLocation W23688780521 @default.
- W2368878052 hasOpenAccess W2368878052 @default.
- W2368878052 hasPrimaryLocation W23688780521 @default.
- W2368878052 hasRelatedWork W1966345111 @default.
- W2368878052 hasRelatedWork W1976001463 @default.
- W2368878052 hasRelatedWork W1981767720 @default.
- W2368878052 hasRelatedWork W1981950917 @default.
- W2368878052 hasRelatedWork W1985490718 @default.
- W2368878052 hasRelatedWork W2004159772 @default.
- W2368878052 hasRelatedWork W2017324812 @default.
- W2368878052 hasRelatedWork W2020276498 @default.
- W2368878052 hasRelatedWork W2026248517 @default.
- W2368878052 hasRelatedWork W2042715009 @default.
- W2368878052 hasRelatedWork W2078086149 @default.
- W2368878052 hasRelatedWork W2090288157 @default.
- W2368878052 hasRelatedWork W2132579123 @default.
- W2368878052 hasRelatedWork W2264309193 @default.
- W2368878052 hasRelatedWork W2407184137 @default.
- W2368878052 hasRelatedWork W2413843913 @default.
- W2368878052 hasRelatedWork W2416671642 @default.
- W2368878052 hasRelatedWork W2418834723 @default.
- W2368878052 hasRelatedWork W2419670048 @default.
- W2368878052 hasRelatedWork W2499553796 @default.
- W2368878052 isParatext "false" @default.
- W2368878052 isRetracted "false" @default.
- W2368878052 magId "2368878052" @default.
- W2368878052 workType "article" @default.