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- W2368882014 abstract "AIM: To investigate the correlation between the expression of transforming growth factor beta (TGFβ) and the angiogenesis in non-small cell lung cancer (NSCLC). METHODS: MVC and expression of TGFβ 1 in 50 carcinomatous specimens and expression of TGFβ 1 in 35 para-carcinomatous specimens from the same 50 cases with NSCLC were detected by SP immunohistochemistry. RESULTS: Active angiogenesis in NSCLC was detected and it was related with NSCLC progression and lymph node metastasis, but not related with histological types. Significant difference of the expression of TGFβ 1 was found between stage Ⅰ and Ⅱ (P0.05), and between stage Ⅰ and Ⅲ (P 0.05) , and the positive expression of TGFβ 1 was significantly higher in the patients with lymph node metastasis than those without lymph node metastasis (P0.01). No significant association was found between the TGFβ 1 expression and the characteristics of the histological types in NSCLC. Positive TGFβ 1 expression in carcinomatous specimen was stronger than that in para-carcinomatous specimen. TGFβ 1 expression was correlated with tumor angiogenesis. CONCLUSION: TGFβ highly promotes the progression and lymph node metastasis of NSCLC, mainly by stimulating angiogenesis." @default.
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- W2368882014 date "2004-01-01" @default.
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- W2368882014 title "Correlation of expression of TGF-beta and angiogenesis in non-small cell lung cancer" @default.
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