Matches in SemOpenAlex for { <https://semopenalex.org/work/W2368913212> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2368913212 abstract "Objective: To explore protective effects of proteinase inhibitor-ulinastatin from cardiovascular disease(myocardial infarction) and its possible mechanism.Methods: A total of 30 Japanese big-ear rabbits(3~5 months old) were chosen.Anterior descending branch of coronary of rabbit was ligated to make model of myocardial infarction.Then the rabbits were randomly and equally divided into control group(received saline),routine treatment group(received routine treatment as nitroglycerin etc.) and ulinastatin group(received ulinastatin based on routine treatment).The patients received echocardiogram examination before and four weeks after treatment.Tetrazolium chloride staining was used to evaluate infarct size,flow cytometry was used to measure apoptosis and enzyme liked immunosorbent assay(ELISA)was used to measure plasma levels of tumor necrosis factor-a(TNF-a) and interleukin-6(IL-6).Results: After treatment,for ulinastatin group left ventricular ejection fraction significantly improved [(56.91±2.04)% vs.(53.22±2.13)% vs.(32.49±1.29)%],infarct size significantly decreased [(21.82±3.12)% vs.(24.61±1.24)% vs.(29.73±2.11)%],apoptosis significantly decreased [(4.98±0.58)% vs.(6.75±0.51)% vs.(9.64±0.23)%];levels of TNF-α [(331.4±13.6) ng/L vs.(391.1±16.9) ng/L vs.(411.5±10.3) ng/L] and IL-6 [(312.2±25.7) ng/L vs.(359.4±30.3) ng/L vs.(409.6±9.1) ng/L] significantly decreased within one week after myocardial infarction compared with routine treatment group and control group(P0.05 all).Levels of inflammatory factors in the three groups showed no significant difference after two weeks(P0.05 all).Conclusion: Ulinastatin possesses protective effect on myocardium,and its mechanism may be related to inhibition of expansion of infarct size,apoptosis and anti-inflammation." @default.
- W2368913212 created "2016-06-24" @default.
- W2368913212 creator A5006178896 @default.
- W2368913212 date "2011-01-01" @default.
- W2368913212 modified "2023-09-23" @default.
- W2368913212 title "Experimental study for protective effects of ulinastatin from cardiovascular disease" @default.
- W2368913212 hasPublicationYear "2011" @default.
- W2368913212 type Work @default.
- W2368913212 sameAs 2368913212 @default.
- W2368913212 citedByCount "0" @default.
- W2368913212 crossrefType "journal-article" @default.
- W2368913212 hasAuthorship W2368913212A5006178896 @default.
- W2368913212 hasConcept C126322002 @default.
- W2368913212 hasConcept C164705383 @default.
- W2368913212 hasConcept C17991360 @default.
- W2368913212 hasConcept C2777397205 @default.
- W2368913212 hasConcept C2778198053 @default.
- W2368913212 hasConcept C2781246285 @default.
- W2368913212 hasConcept C42219234 @default.
- W2368913212 hasConcept C500558357 @default.
- W2368913212 hasConcept C71924100 @default.
- W2368913212 hasConcept C78085059 @default.
- W2368913212 hasConcept C90924648 @default.
- W2368913212 hasConceptScore W2368913212C126322002 @default.
- W2368913212 hasConceptScore W2368913212C164705383 @default.
- W2368913212 hasConceptScore W2368913212C17991360 @default.
- W2368913212 hasConceptScore W2368913212C2777397205 @default.
- W2368913212 hasConceptScore W2368913212C2778198053 @default.
- W2368913212 hasConceptScore W2368913212C2781246285 @default.
- W2368913212 hasConceptScore W2368913212C42219234 @default.
- W2368913212 hasConceptScore W2368913212C500558357 @default.
- W2368913212 hasConceptScore W2368913212C71924100 @default.
- W2368913212 hasConceptScore W2368913212C78085059 @default.
- W2368913212 hasConceptScore W2368913212C90924648 @default.
- W2368913212 hasLocation W23689132121 @default.
- W2368913212 hasOpenAccess W2368913212 @default.
- W2368913212 hasPrimaryLocation W23689132121 @default.
- W2368913212 hasRelatedWork W154346771 @default.
- W2368913212 hasRelatedWork W2142645828 @default.
- W2368913212 hasRelatedWork W2351538095 @default.
- W2368913212 hasRelatedWork W2370358960 @default.
- W2368913212 hasRelatedWork W2400957367 @default.
- W2368913212 hasRelatedWork W2405916776 @default.
- W2368913212 hasRelatedWork W2408853602 @default.
- W2368913212 hasRelatedWork W2412447965 @default.
- W2368913212 hasRelatedWork W2413684616 @default.
- W2368913212 hasRelatedWork W2461045643 @default.
- W2368913212 hasRelatedWork W2559742135 @default.
- W2368913212 hasRelatedWork W2587859338 @default.
- W2368913212 hasRelatedWork W2805432571 @default.
- W2368913212 hasRelatedWork W2978576587 @default.
- W2368913212 hasRelatedWork W3028894052 @default.
- W2368913212 hasRelatedWork W3029870134 @default.
- W2368913212 hasRelatedWork W3031533242 @default.
- W2368913212 hasRelatedWork W3031751670 @default.
- W2368913212 hasRelatedWork W3032518389 @default.
- W2368913212 hasRelatedWork W3032701547 @default.
- W2368913212 isParatext "false" @default.
- W2368913212 isRetracted "false" @default.
- W2368913212 magId "2368913212" @default.
- W2368913212 workType "article" @default.