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- W2368915398 abstract "Objective: To research the effects of Zhali Nusi fang( ZLNSF) on the permeability changes of blood brain barrier after focal cerebral ischemia-reperfusion in rats. Method: SD rats were divided randomLy into Sham-operated,model,nimodipine and ZLNSF groups. Rat focal cerebral ischemia-reperfusion model was established by middle cerebral artery occlusion with nylon thread. Afte rats were administered orally with corresponding drugs 1,3,7,14 d,then take out brain. The neurological scores were evaluated. Wet and dry weight measured brain water content; immunohistochemical method to measure IgG expression. Result: Compared with the Sham-operated group,ischemia reperfusion brain water content,IgG expression was significantly increased( P 0. 01,P 0. 05),neurological function score significantly dropped( P 0. 01); compared with the model group,the nimodipine group of brain water content,neurological function score emerged varying degrees of improvement( P 0. 05),the expression of IgG level decreased,especially in 3,7 d significantly( P 0. 01); compared with nimodipine group,ZLNSF group brain water content,IgG expression was emerged varying degrees down( P 0. 05),and nerve function integral increases especially in 3,7 d; compared with 1 d,ZLNSF 3,7 d groups the expression of IgG levels were significantly lower( P 0. 05). Conclusion: Cerebral ischemia-reperfusion injury can induced breakdown and increased permeability of the blood-brain barrier after 1-7 d,then the blood-brain barrier permeability gradually restored after seven days; it is indicated that the treatment of the ZLNSF can promote the cerebral protection. Its mechanism may be related to down-regulate the expression of IgG and reduce the permeability of blood-brain barrier,hold back harmful and large molecules from entering the brain,which plays a critical protective effect." @default.
- W2368915398 created "2016-06-24" @default.
- W2368915398 creator A5021213414 @default.
- W2368915398 date "2014-01-01" @default.
- W2368915398 modified "2023-09-23" @default.
- W2368915398 title "Effects of Zhali Nusi Fang on Permeability Changes of Blood Brain Barrier after Focal Cerebral Ischemia-reperfusion in Rats" @default.
- W2368915398 hasPublicationYear "2014" @default.
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