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- W2368933923 abstract "In this study, eight kinds of fumaric acid amino acid ester derivatives were synthesized through amidation and isomerization, by using maleic anhydride and amino acid ester as raw materials and anhydrous aluminium chloride as an isomerization catalyst. Using a ratio of maleic anhydride to amino-acid ester to anhydrous aluminum chloride as 0.2 mol:0.2 mol:1.0 g, the yield of these products was more than 75%. The molecular structure of the compounds was determined by melting point determination and 1H nuclear magnetic resonance imaging. Antimicrobial activity of these compounds against Escherichia coli, Staphylococcus aureus, Salmonella sp., Bacillus subtilis, Lactobacillus sp., bacteria causing milk spoilage, as well as skin smear tests were conducted. The results showed that the minimum inhibitory concentration of fumaric acid amino acid ester derivatives were comparable to that of dimethyl fulminate. Moreover, fumaric acid amino acid ester derivatives did not cause skin allergy, while dimethyl fumarate caused strong skin allergic reactions(red rash). Cell viability of normal liver cells(L02) and hepatoma cells(HepG2) exposed to fumaric acid amino acid ester derivatives was also evaluated, which showed no toxic effect on either cell type." @default.
- W2368933923 created "2016-06-24" @default.
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- W2368933923 date "2014-01-01" @default.
- W2368933923 modified "2023-09-26" @default.
- W2368933923 title "Synthesis and Antimicrobial Activity of Fumaric Acid Amino Acid Ester Derivatives" @default.
- W2368933923 hasPublicationYear "2014" @default.
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