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- W2368942968 abstract "Objective To observe the chemotactic effect of wound extract from human on epidermal stem cells(ESCs),and to investigate the mechanism of the chemotaixs.Methods The expression of CXCR4(the only known receptor of SDF-1) in ESCs were examined by using immunoflouresence and flow cytometry(FCM).Using Transwell microchemotaxis chamber system,we observed the effect of wound extract on the migration of ESCs.Results Firstly,ESCs expressed CXCR4.The wound extract significantly promoted migration of ESCs across the membrane of the microchemotaxis chamber,when the antibody blocking CXCR4 was added,the chemotactic effect of ESCs was significantly reduced(P0.01).Conclusion Our results suggest that wound extract from human can enhance the migration of ESCs in vitro,and we supposed that SDF-1 as the only ligand of CXCR4 probably reside in wound extract from human." @default.
- W2368942968 created "2016-06-24" @default.
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- W2368942968 date "2007-01-01" @default.
- W2368942968 modified "2023-09-28" @default.
- W2368942968 title "Experimental study on chemotanctic effect of wound extract from human on epidermal stem cell in vitro" @default.
- W2368942968 hasPublicationYear "2007" @default.
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