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- W2368943552 abstract "Objective:The genotoxicity and its molecular mechanism of gasoline vehicle exhaust were studied through examining exhaust components and the oxidative DNA damage induced by them. Methods: DNA adduct,8-hydroxy deoxyguanosine (8-OHdG),was used as a biomarker of oxidative DNA damage. The level of 8-OHdG in DNA exposed to gasoline vehicle exhaust was measured by high performance liquid chromatography-electrochemical detection method(HPLC-EC) in vitro and in vivo. Organic and inorganic components in gasoline vehicle exhaust were analyzed by gas chromatography-mass spectrometry (GC-MS) and atomic absorption spectrometry(AAS)respectively. Results:There were 85 and 46 kinds of organic compounds, 7 and 5 kinds of inorganic compounds respectively in the particles and volatile organic compounds (VOCs) of gasoline vehicle exhaust. In addition,the particles and VOCs of gasoline vehicle exhaust could directly induce oxidative DNA damage.The particles could also induce oxidative DNA damage of rat lung tissues to form 8-OHdG with dose-response relationship. Conclusion: The main reason of the oxidative DNA damage is that gasoline vehicle exhaust contains a lot of polyphenol and quinone compounds which may further produce large amounts of active oxygen free radicals in vitro, without any biological activating system, to attack DNA and to form 8-OHdG and genotoxicity by the catalysis of metal ions. 8-OHdG is a better effect biomarker of oxidative DNA damage." @default.
- W2368943552 created "2016-06-24" @default.
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- W2368943552 date "2003-01-01" @default.
- W2368943552 modified "2023-09-25" @default.
- W2368943552 title "A STUDY ON THE OXIDATIVE DNA DAMAGE INDUCED BY GASOLINE VEHICLE EXHAUST" @default.
- W2368943552 hasPublicationYear "2003" @default.
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