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- W2368972596 abstract "Objective To study the expression of Livin, an apoptosis inhibitor gene,in tissues of transitional cell carcinoma of bladder and to investigate its clinical and pathological implications. Methods RT-PCR was used to determine the expression of Livin in 36 cases (31 men and 12 women) of TCC and 12 cases of normal bladder tissues (controls).The mean age of the 36 cases at diagnosis was 64 years.The pathological grading were GradeⅠin 10 cases, GradeⅡin 23 cases,and Grade Ⅲ in 3 cases.The clinical staging were T_1 in 22 cases,T_2 in 9 cases,T_3 in 3cases,T_4 in 2 cases.Of the 36 cases,25 primary and 11 recurrent,19 single and 17 multiple fuci. Results Livin mRNA was expressed in 28 of 36 TCC cases (78%).The positive rate of Livin expression in T_1,T_2~T_4,Ⅰ,Ⅱ,Ⅲ,single,multiple,primary, recurrent was 82%(18/22),71%(10/14),70%(7/10),83%(19/23),67%(2/3),79%(15/19),76%(13/17),80%(20/25),73%(8/11).Livin showed no correlated with the grade,stage,focus number and recurrent status.There was no expression in control group. The positive rate of Livin between TCC and control was significant. Conclusions It is indicated that Livin may play a significant role in the TCC development.Livin might be a biomarker for the detection of TCC and served as a new target for apoptosis-inducing therapy of TCC." @default.
- W2368972596 created "2016-06-24" @default.
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- W2368972596 date "2006-01-01" @default.
- W2368972596 modified "2023-09-28" @default.
- W2368972596 title "Expression of apoptosis inhibitor gene Livin in bladder carcinoma and its clinical implication" @default.
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