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- W2368976775 abstract "Purpose To study the role of extracellular signal regulated kinases (ERKs) in cerebral ischemia and the mechanism of protective effects of U0126 on ischemic brain. Methods Mice underwent left middle cerebral artery occlusion (MCAO) by introducing a suture in the lumen.U0126 was injected intravenously through the internal jugular vein.Phosphorylated MEK (pMEK),phosphorylated ERK1/2(pERK1/2),and phosphorylated Elk-1(pElk-1) was determined by Western blot analysis or immunohistochemistry.Interleukin (IL)-1β mRNA level was measured by ribonuclease protection assay. Results pMEK was reduced in ischemic mice after U0126 injection.The reduction was dose dependent and treatment time related.pERK1/2 and pElk-1 were also reduced in a similar pattern.IL-1β mRNA increased during 1 to 2 h of MCAO.After injection of U0126,it was down-regulated during 1 to 4 h of MCAO. Conclusions ERK cascade plays a critical role in cerebral ischemia.The protective effect of U0126 against ischemic injury is probably achieved by reduction of IL-1β mRNA via the inhibition of ERK pathway." @default.
- W2368976775 created "2016-06-24" @default.
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- W2368976775 date "2004-01-01" @default.
- W2368976775 modified "2023-09-28" @default.
- W2368976775 title "MEK Inhibitor Prevents ERK Cascade Activation and IL-1β mRNA Production after Cerebral Ischemia in Mice" @default.
- W2368976775 hasPublicationYear "2004" @default.
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