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- W2368978314 abstract "Objective To carry out a meta-analysis to evaluate the efficacy and safety of dexmedetomidine in comparison with midazolam as preoperative drug. Methods All randomized controlled trials (RCTs) about dexmedetomidine as preoperative drug compared with midazolam were identified. Meta analysis was performed by using the statistical software RevMan 4.2.10 on the basis of strict quality evaluation. Results Thirteen RCTs involving 806 patients were included. The results of meta analyses showed that dexmedetomidine was better than midazolam in decreasing perioperative blood pressure and heart rate,decreasing dosage of anesthetics,shortening of emergence time,and decreasing the occurrence of agitation,while the occurrence of perioperative hypotention and bradycardia of dexmedetomidine was much more than midazolam. The statistical outcomes showed that there were no differences between the two drugs in the satisfactory score,postoperative sedation score,the number of people needing analgesia,and occurrence of nausea and vomitting. Conclusion Significant advantages in favour of dexmedetomidine as preoperative drug are observed. Dexmedetomidine is safe except for more incidences of hypotension and bradycardia." @default.
- W2368978314 created "2016-06-24" @default.
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- W2368978314 date "2009-01-01" @default.
- W2368978314 modified "2023-09-26" @default.
- W2368978314 title "Dexmedetomidine versus Midazolam in Anesthetic Preoperative Administration:A Meta-analysis" @default.
- W2368978314 hasPublicationYear "2009" @default.
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